Somatotroph Tumors and the Epigenetic Status of the GNAS Locus

Forty percent of somatotroph tumors harbor recurrent activating GNAS mutations, historically called the gsp oncogene. In gsp-negative somatotroph tumors, GNAS expression itself is highly variable; those with GNAS overexpression most resemble phenotypically those carrying the gsp oncogene. GNAS is mo...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Romanet, Pauline, Galluso, Justine, Kamenicky, Peter, Hage, Mirella, Theodoropoulou, Marily, Roche, Catherine, Graillon, Thomas, Etchevers, Heather C., De Murat, Daniel, Mougel, Grégory, Figarella-Branger, Dominique, Dufour, Henry, Cuny, Thomas, Assié, Guillaume, Barlier, Anne
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306130/
https://ncbi.nlm.nih.gov/pubmed/34299200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147570
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