Dose-Dependent Dual Role of PIT-1 (POU1F1) in Somatolactotroph Cell Proliferation and Apoptosis

To test the role of wtPIT-1 (PITWT) or PIT-1 (R271W) (PIT271) in somatolactotroph cells, we established, using inducible lentiviral vectors, sublines of GH4C1 somatotroph cells that allow the blockade of the expression of endogenous PIT-1 and/or the expression of PITWT or PIT271, a dominant negative...

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Bibliographic Details
Published in:PLoS One
Main Authors: Jullien, Nicolas, Roche, Catherine, Brue, Thierry, Figarella-Branger, Dominique, Graillon, Thomas, Barlier, Anne, Herman, Jean-Paul
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379079/
https://ncbi.nlm.nih.gov/pubmed/25822178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120010
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