Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas

As the cornerstone of high-grade glioma (HGG) treatment, radiotherapy temporarily controls tumor cells via inducing oxidative stress and subsequent DNA breaks. However, almost all HGGs recur within months. Therefore, it is important to understand the underlying mechanisms of radioresistance, so that...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Cook, Kristina M., Shen, Han, McKelvey, Kelly J., Gee, Harriet E., Hau, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305417/
https://ncbi.nlm.nih.gov/pubmed/34298883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147265
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