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New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations

Pharmacokinetic (PK) studies improve the design of dosing regimens in preclinical and clinical settings. In complex diseases like cancer, single-agent approaches are often insufficient for an effective treatment, and drug combination therapies can be implemented. In this work, in silico PK models we...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Correia, Cristiana, Ferreira, Abigail, Santos, Joana, Lapa, Rui, Yliperttula, Marjo, Urtti, Arto, Vale, Nuno
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304213/
https://ncbi.nlm.nih.gov/pubmed/34299532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26144257
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