Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux

SIMPLE SUMMARY: Innate and acquired platinum resistance are the leading causes of epithelial ovarian cancer (EOC) mortality. However, the mechanisms remain elusive. Here we found that Exo70, a key subunit of the exocyst, is upregulated in EOC and promotes cisplatin efflux to facilitate innate resist...

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Udgivet i:Cancers (Basel)
Main Authors: Zhao, Yujie, Hong, Xiaoting, Chen, Xiong, Hu, Chun, Lu, Weihong, Xie, Baoying, Zhong, Linhai, Zhang, Wenqing, Cao, Hanwei, Chen, Binbin, Liu, Qian, Zhan, Yanyan, Xiao, Li, Hu, Tianhui
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304026/
https://ncbi.nlm.nih.gov/pubmed/34298686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143467
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