Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity

Background: The proximal tubule (PT) is the major target of cadmium (Cd(2+)) nephrotoxicity. Current dogma postulates that Cd(2+) complexed to metallothionein (MT) (CdMT) is taken up through receptor-mediated endocytosis (RME) via the PT receptor megalin:cubilin, which is the predominant pathway for...

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Udgivet i:Int J Mol Sci
Main Authors: Zavala-Guevara, Itzel Pamela, Ortega-Romero, Manolo Sibael, Narváez-Morales, Juana, Jacobo-Estrada, Tania Libertad, Lee, Wing-Kee, Arreola-Mendoza, Laura, Thévenod, Frank, Barbier, Olivier Christophe
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8303618/
https://ncbi.nlm.nih.gov/pubmed/34298880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147262
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