Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis

Several studies have demonstrated that melanoma-derived extracellular vesicles (EVs) are involved in lymph node metastasis; however, the molecular mechanisms involved are not completely defined. Here, we found that EMILIN-1 is proteolyzed and secreted in small EVs (sEVs) as a novel mechanism to redu...

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Udgivet i:Int J Mol Sci
Main Authors: Amor López, Ana, Mazariegos, Marina S., Capuano, Alessandra, Ximénez-Embún, Pilar, Hergueta-Redondo, Marta, Recio, Juan Ángel, Muñoz, Eva, Al-Shahrour, Fátima, Muñoz, Javier, Megías, Diego, Doliana, Roberto, Spessotto, Paola, Peinado, Héctor
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8303474/
https://ncbi.nlm.nih.gov/pubmed/34299025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147406
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