Coxsackievirus B4 Transplacental Infection Severely Disturbs Central Tolerogenic Mechanisms in the Fetal Thymus

Thymus plays a fundamental role in central tolerance establishment, especially during fetal life, through the generation of self-tolerant T cells. This process consists in T cells education by presenting them tissue-restricted autoantigens promiscuously expressed by thymic epithelial cells (TECs), t...

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Veröffentlicht in:Microorganisms
Hauptverfasser: Halouani, Aymen, Michaux, Hélène, Jmii, Habib, Trussart, Charlotte, Chahbi, Ahlem, Martens, Henri, Renard, Chantal, Aouni, Mahjoub, Hober, Didier, Geenen, Vincent, Jaïdane, Hela
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8303261/
https://ncbi.nlm.nih.gov/pubmed/34361972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms9071537
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