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Presynaptic GABA(B) receptor–mediated network excitation in the medial prefrontal cortex of Tsc2(+/-) mice

The TSC1 and TSC2 tumor suppressor genes control the activity of mechanistic target of rapamycin (mTOR) pathway. Elevated activity of this pathway in Tsc2(+/-) mouse model leads to reduction of postsynaptic GABA(B) receptor–mediated inhibition and hyperexcitability in the medial prefrontal cortex (m...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Bassetti, Davide, Luhmann, Heiko J., Kirischuk, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302497/
https://ncbi.nlm.nih.gov/pubmed/34279736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-021-02576-5
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