Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat

Remdesivir is a nucleotide analog prodrug that has received much attention since the outbreak of the COVID-19 pandemic in December 2019. GS-441524 (Nuc) is the active metabolite of remdesivir and plays a pivotal role in the clinical treatment of COVID-19. Here, a robust HPLC-MS/MS method was develop...

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Udgivet i:Anal Bioanal Chem
Main Authors: Du, Ping, Wang, Guoyong, Yang, Song, Li, Pengfei, Liu, Lihong
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302467/
https://ncbi.nlm.nih.gov/pubmed/34302183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-021-03561-8
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