Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study

This study aimed to develop a selective, simple, and sensitive HPLC-MS/MS method for the simultaneous determination of schisandrin and promethazine (PMZ) with its metabolite in rat plasma, which was further used for a pharmacokinetic herb-drug interaction study. HPLC-MS/MS analyses were performed on...

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Detalhes bibliográficos
Publicado no:Int J Anal Chem
Main Authors: Gao, Sijia, Zhou, Xuelin, Lang, Liwei, Liu, Honghong, Li, Jianyu, Li, Haotian, Wei, Shizhang, Wang, Dan, Xu, Zhuo, Cai, Huadan, Zhao, Yanling, Zou, Wenjun
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925819/
https://ncbi.nlm.nih.gov/pubmed/31885590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3497045
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