Pharmacodynamic analysis of BTK inhibition in patients with chronic lymphocytic leukemia treated with acalabrutinib

PURPOSE: To determine the pharmacodynamic relationship between target occupancy of Bruton’s tyrosine kinase (BTK) and inhibition of downstream signaling. EXPERIMENTAL DESIGN: Patients with Chronic Lymphocytic Leukemia (CLL) enrolled on a phase 2 clinical trial (NCT02337829) with the covalent, select...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Alsadhan, Anfal, Cheung, Jean, Gulrajani, Michael, Gaglione, Erika M., Nierman, Pia, Hamdy, Ahmed, Izumi, Raquel, Bibikova, Elena, Patel, Priti, Sun, Clare, Covey, Todd, Herman, Sarah E. M., Wiestner, Adrian
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301526/
https://ncbi.nlm.nih.gov/pubmed/32054731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3505
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