Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib

Inhibition of the B-cell receptor pathway, and specifically of Bruton tyrosine kinase (BTK), is a leading therapeutic strategy in B-cell malignancies, including chronic lymphocytic leukemia (CLL). Target occupancy is a measure of covalent binding to BTK and has been applied as a pharmacodynamic para...

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發表在:Blood
Main Authors: Sun, Clare, Nierman, Pia, Kendall, Ellen K., Cheung, Jean, Gulrajani, Michael, Herman, Sarah E. M., Pleyer, Christopher, Ahn, Inhye E., Stetler-Stevenson, Maryalice, Yuan, Constance M., Maric, Irina, Gaglione, Erika M., Harris, Hailey M., Pittaluga, Stefania, Wang, Min Hui, Patel, Priti, Farooqui, Mohammed Z. H., Izumi, Raquel, Hamdy, Ahmed, Covey, Todd, Wiestner, Adrian
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2020
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332900/
https://ncbi.nlm.nih.gov/pubmed/32202637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003715
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