ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity()

Although the role of hydrophilic antioxidants in the development of hepatic insulin resistance and non-alcoholic fatty liver disease (NAFLD) has been well studied, the role of lipophilic antioxidants remains poorly characterized. A known lipophilic H(2)O(2) scavenger is bilirubin, which can be oxidi...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Shum, Michael, Shintre, Chitra A., Althoff, Thorsten, Gutierrez, Vincent, Segawa, Mayuko, Saxberg, Alexandra D., Martinez, Melissa, Adamson, Roslin, Young, Margaret R., Faust, Belinda, Gharakhanian, Raffi, Su, Shi, Krishnan, Karthickeyan Chella, Mahdaviani, Kiana, Veliova, Michaela, Wolf, Dane M., Ngo, Jennifer, Nocito, Laura, Stiles, Linsey, Abramson, Jeff, Lusis, Aldons J., Hevener, Andrea L., Zoghbi, Maria E., Carpenter, Elisabeth P., Liesa, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8300486/
https://ncbi.nlm.nih.gov/pubmed/34011630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd1869
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