Indices of Defective Autophagy in Whole Muscle and Lysosome Enriched Fractions From Aged D2-mdx Mice

Duchenne muscular dystrophy (DMD) is a fatal, progressive muscle disease caused by the absence of functional dystrophin protein. Previous studies in mdx mice, a common DMD model, identified impaired autophagy with lysosomal insufficiency and impaired autophagosomal degradation as consequences of dys...

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Udgivet i:Front Physiol
Main Authors: Krishna, Swathy, Spaulding, Hannah R., Quindry, Tiffany S., Hudson, Matthew B., Quindry, John C., Selsby, Joshua T.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299564/
https://ncbi.nlm.nih.gov/pubmed/34305644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.691245
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