Predicting Aggressive Multiple Sclerosis With Intrathecal IgM Synthesis Among Patients With a Clinically Isolated Syndrome

OBJECTIVE: To determine the best method to measure intrathecal immunoglobulin (Ig) M synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared the ability for predicting a poor evolution of 4 methods assessing ITMS (IgM oligoclonal bands [OCMBs], lipid-specific OCMBs [...

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Pubblicato in:Neurol Neuroimmunol Neuroinflamm
Autori principali: Monreal, Enric, Sainz de la Maza, Susana, Costa-Frossard, Lucienne, Walo-Delgado, Paulette, Zamora, Javier, Fernández-Velasco, José Ignacio, Villarrubia, Noelia, Espiño, Mercedes, Lourido, Daniel, Lapuente, Paloma, Toboso, Inmaculada, Álvarez-Cermeño, José Carlos, Masjuan, Jaime, Villar, Luisa María
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299514/
https://ncbi.nlm.nih.gov/pubmed/34301819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000001047
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