New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes

[Image: see text] Positron Emission Tomography (PET) imaging with antibody-based contrast agents frequently uses the radioisotopes [(64)Cu]Cu(2+) and [(89)Zr]Zr(4+). The macrobicyclic chelator commonly known as sarcophagine (sar) is ideal for labeling receptor-targeted biomolecules with [(64)Cu]Cu(2...

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Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Farleigh, Matthew, Pham, Truc Thuy, Yu, Zilin, Kim, Jana, Sunassee, Kavitha, Firth, George, Forte, Nafsika, Chudasama, Vijay, Baker, James R., Long, Nicholas J., Rivas, Charlotte, Ma, Michelle T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299457/
https://ncbi.nlm.nih.gov/pubmed/33724798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.0c00710
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