Inactivation of Cerebral Cavernous Malformation Genes Results in Accumulation of von Willebrand Factor and Redistribution of Weibel-Palade Bodies in Endothelial Cells

Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits. Our understanding of the cellular and molecular mechanisms t...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Much, Christiane D., Sendtner, Barbara S., Schwefel, Konrad, Freund, Eric, Bekeschus, Sander, Otto, Oliver, Pagenstecher, Axel, Felbor, Ute, Rath, Matthias, Spiegler, Stefanie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298835/
https://ncbi.nlm.nih.gov/pubmed/34307446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.622547
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