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Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological significance of afatinib-induced autophagy in HNS...
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| 發表在: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8298552/ https://ncbi.nlm.nih.gov/pubmed/34294686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-04011-0 |
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