Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. However, the detailed mechanism and biological significance of afatinib-induced autophagy in HNS...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Liu, Xianfang, Suo, Huiyuan, Zhou, Shengli, Hou, Zhenxing, Bu, Mingqiang, Liu, Xiuxiu, Xu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298552/
https://ncbi.nlm.nih.gov/pubmed/34294686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-04011-0
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