Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human population and require effective medical countermeasures. Engineered mutants of the Brevundimonas diminuta phosphotriesterase (BdPTE) exhibit enhanced...

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Dettagli Bibliografici
Pubblicato in:Arch Toxicol
Autori principali: Köhler, Anja, Escher, Benjamin, Job, Laura, Koller, Marianne, Thiermann, Horst, Skerra, Arne, Worek, Franz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2021
Soggetti:
Organ Toxicity and Mechanisms
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298220/
https://ncbi.nlm.nih.gov/pubmed/34160649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03094-0
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