Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human population and require effective medical countermeasures. Engineered mutants of the Brevundimonas diminuta phosphotriesterase (BdPTE) exhibit enhanced...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Köhler, Anja, Escher, Benjamin, Job, Laura, Koller, Marianne, Thiermann, Horst, Skerra, Arne, Worek, Franz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2021
Pynciau:
Organ Toxicity and Mechanisms
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298220/
https://ncbi.nlm.nih.gov/pubmed/34160649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03094-0
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg