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Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice

BACKGROUND: Alcohol Use Disorder (AUD) is a complex psychiatric disease characterized by high alcohol intake as well as by hyperkatifeia and hyperalgesia during withdrawal. A role for Sigma-1 Receptors (Sig-1Rs) in the rewarding and reinforcing effects of alcohol has started to emerge in recent year...

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Bibliografiske detaljer
Udgivet i:Alcohol Clin Exp Res
Main Authors: Quadir, Sema G., Tanino, Sean M., Sami, Yasmine N., Minnig, Margaret A., Iyer, Malliga R., Rice, Kenner C., Cottone, Pietro, Sabino, Valentina
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295198/
https://ncbi.nlm.nih.gov/pubmed/34060104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.14635
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