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The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

All membrane fusion reactions proceed through an initial fusion pore, including calcium-triggered release of neurotransmitters and hormones. Expansion of this small pore to release cargo is energetically costly and regulated by cells, but the mechanisms are poorly understood. Here, we show that the...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wu, Zhenyong, Dharan, Nadiv, McDargh, Zachary A, Thiyagarajan, Sathish, O'Shaughnessy, Ben, Karatekin, Erdem
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294851/
https://ncbi.nlm.nih.gov/pubmed/34190041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68215
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