Local IP(3) receptor–mediated Ca(2+) signals compound to direct blood flow in brain capillaries

Healthy brain function depends on the finely tuned spatial and temporal delivery of blood-borne nutrients to active neurons via the vast, dense capillary network. Here, using in vivo imaging in anesthetized mice, we reveal that brain capillary endothelial cells control blood flow through a hierarchy...

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Vydáno v:Sci Adv
Hlavní autoři: Longden, Thomas A., Mughal, Amreen, Hennig, Grant W., Harraz, Osama F., Shui, Bo, Lee, Frank K., Lee, Jane C., Reining, Shaun, Kotlikoff, Michael I., König, Gabriele M., Kostenis, Evi, Hill-Eubanks, David, Nelson, Mark T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294755/
https://ncbi.nlm.nih.gov/pubmed/34290098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh0101
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