A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cells

c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc–MAX heterodimer regulates the expression of several genes, leading to an oncogeni...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Singh, Ashutosh, Kumar, Ankur, Kumar, Prateek, Nayak, Namyashree, Bhardwaj, Taniya, Giri, Rajanish, Garg, Neha
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294579/
https://ncbi.nlm.nih.gov/pubmed/34157284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100903
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