Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor microenvironment that renders it largely refractory to immunotherapy. We implemented a multimodal analysis approach to elucidate the immune landscape in PDA. Using a combination of CyTOF, single-cell RNA sequencin...

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Veröffentlicht in:Nat Cancer
Hauptverfasser: Steele, Nina G., Carpenter, Eileen S., Kemp, Samantha B., Sirihorachai, Veerin, The, Stephanie, Delrosario, Lawrence, Lazarus, Jenny, Amir, El-ad David, Gunchick, Valerie, Espinoza, Carlos, Bell, Samantha, Harris, Lindsey, Lima, Fatima, Irizarry-Negron, Valerie, Paglia, Daniel, Macchia, Justin, Chu, Angel Ka Yan, Schofield, Heather, Wamsteker, Erik-Jan, Kwon, Richard, Schulman, Allison, Prabhu, Anoop, Law, Ryan, Sondhi, Arjun, Yu, Jessica, Patel, Arpan, Donahue, Katelyn, Nathan, Hari, Cho, Clifford, Anderson, Michelle A., Sahai, Vaibhav, Lyssiotis, Costas A., Zou, Weiping, Allen, Benjamin L., Rao, Arvind, Crawford, Howard C., Bednar, Filip, Frankel, Timothy L., Pasca di Magliano, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294470/
https://ncbi.nlm.nih.gov/pubmed/34296197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00121-4
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