Thermoplastic Nanofluidic Devices for Identifying Abasic Sites in Single DNA Molecules

DNA damage can take many forms such as double-strand breaks and/or the formation of abasic (apurinic/apyrimidinic; AP) sites. The presence of AP sites can be used to determine therapeutic efficacy of many drugs, such as doxorubicin. While there are different assays to search for DNA damage, they are...

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Udgivet i:Lab Chip
Main Authors: Vaidyanathan, Swarnagowri, Weerakoon-Ratnayake, Kumuditha M., Uba, Franklin I., Hu, Bo, Kaufman, David, Choi, Junseo, Park, Sunggook, Soper, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293902/
https://ncbi.nlm.nih.gov/pubmed/33651049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0lc01038c
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