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Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus

To compare lupus pathogenesis in disparate tissues, we analyzed gene expression profiles of human discoid lupus erythematosus (DLE) and lupus nephritis (LN). We found common increases in myeloid cell-defining gene sets and decreases in genes controlling glucose and lipid metabolism in lupus-affected...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kingsmore, Kathryn M., Bachali, Prathyusha, Catalina, Michelle D., Daamen, Andrea R., Heuer, Sarah E., Robl, Robert D., Grammer, Amrie C., Lipsky, Peter E.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292402/
https://ncbi.nlm.nih.gov/pubmed/34285256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93034-w
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