Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer

Studies in three mouse models of breast cancer identified profound discrepancies between cell autonomous and systemic Akt1 or Akt2 inducible deletion on breast cancer tumorigenesis and metastasis. While systemic Akt1 deletion, inhibits metastasis, cell autonomous Akt1 deletion does not. Single cell...

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Pubblicato in:Mol Cell
Autori principali: Chen, Xinyu, Ariss, Majd M., Ramakrishnan, Gopalakrishnan, Nogueira, Veronique, Blaha, Catherine, Putzbach, William, Islam, Abul B. M. M. K., Frolov, Maxim V., Hay, Nissim
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291754/
https://ncbi.nlm.nih.gov/pubmed/32931746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.017
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