Cell autonomous versus systemic Akt isoform deletions uncovered new roles for Akt1 and Akt2 in breast cancer

Studies in three mouse models of breast cancer identified profound discrepancies between cell autonomous and systemic Akt1 or Akt2 inducible deletion on breast cancer tumorigenesis and metastasis. While systemic Akt1 deletion, inhibits metastasis, cell autonomous Akt1 deletion does not. Single cell...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Chen, Xinyu, Ariss, Majd M., Ramakrishnan, Gopalakrishnan, Nogueira, Veronique, Blaha, Catherine, Putzbach, William, Islam, Abul B. M. M. K., Frolov, Maxim V., Hay, Nissim
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291754/
https://ncbi.nlm.nih.gov/pubmed/32931746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.017
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