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BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role in migration towards SDF-1
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b(+) or CD11c(+) B cells whose presence was an unfavourable prognostic factor. The exact mechanism however, how these receptors contribute...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8291664/ https://ncbi.nlm.nih.gov/pubmed/34283878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254853 |
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