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Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction

[Image: see text] Highly substituted isoquinolone-4-carboxylic acid is an important bioactive scaffold; however, it is challenging to access it in a general and short way. A Cu-catalyzed cascade reaction was successfully designed involving the Ugi postcyclization strategy by using ammonia and 2-halo...

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Detalhes bibliográficos
Publicado no:J Org Chem
Main Authors: Wang, Qian, Mgimpatsang, Kumchok C., Li, Xin, Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291606/
https://ncbi.nlm.nih.gov/pubmed/34184894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.1c01170
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