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TNF stimulation primarily modulates transcriptional burst size of NF‐κB‐regulated genes

Cell‐to‐cell heterogeneity is a feature of the tumor necrosis factor (TNF)‐stimulated inflammatory response mediated by the transcription factor NF‐κB, motivating an exploration of the underlying sources of this noise. Here, we combined single‐transcript measurements with computational models to stu...

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Publicat a:Mol Syst Biol
Autors principals: Bass, Victor L, Wong, Victor C, Bullock, M Elise, Gaudet, Suzanne, Miller‐Jensen, Kathryn
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290835/
https://ncbi.nlm.nih.gov/pubmed/34288498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.202010127
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