HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

Adoptive cellular immunotherapy therapy using broadly neutralizing antibody-based chimeric antigen receptor-T cells (bNAb-based CAR-T) has shown great potency and safety for the functional cure of HIV. The efficacy of bNAb-based CAR-T cells could be compromised by adaptive resistance during HIV chro...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Jiang, Zhengtao, Liang, Huitong, Pan, Hanyu, Liang, Yue, Wang, Hua, Yang, Xinyi, Lu, Panpan, Zhang, Xiao, Yang, Jinlong, Zhang, Dengji, Shen, Xiaoting, Wang, Jing, Liang, Zhiming, Lin, Qinru, Wang, Yanan, Zhao, Lin, Zhong, Yangcheng, Lu, Hongzhou, Zhu, Huanzhang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290485/
https://ncbi.nlm.nih.gov/pubmed/34295319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2021.684016
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