Implementation and implications for polygenic risk scores in healthcare

Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWASs), are able to stratify individuals based on their genetic risk of developing various com...

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Vydáno v:Hum Genomics
Hlavní autoři: Slunecka, John L., van der Zee, Matthijs D., Beck, Jeffrey J., Johnson, Brandon N., Finnicum, Casey T., Pool, René, Hottenga, Jouke-Jan, de Geus, Eco J. C., Ehli, Erik A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290135/
https://ncbi.nlm.nih.gov/pubmed/34284826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40246-021-00339-y
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