Reduced TGF-β Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice

Age is a key factor in intervertebral disc (IVD) degeneration; however, the changes that occur in IVDs with age are not fully understood. Tissue-resident macrophages are critical for tissue homeostasis and are regulated by transforming growth factor- (TGF-) β. We examined changes in the proportion o...

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Veröffentlicht in:Biomed Res Int
Hauptverfasser: Yokozeki, Yuji, Kawakubo, Ayumu, Miyagi, Masayuki, Kuroda, Akiyoshi, Sekiguchi, Hiroyuki, Inoue, Gen, Takaso, Masashi, Uchida, Kentaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289593/
https://ncbi.nlm.nih.gov/pubmed/34337052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/7988320
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