Efficacy of Methotrexate on Rat Knee Osteoarthritis Induced by Monosodium Iodoacetate

OBJECTIVE: To explore whether methotrexate (MTX) prevents joint destruction and improves pain-related behaviors in the acute phase of knee osteoarthritis (OA) induced by monosodium iodoacetate (MIA) in a rat model. METHODS: Twenty of 25 male Wistar rats (10–14 weeks old) received 3 mg MIA via intra-...

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Bibliografske podrobnosti
izdano v:J Inflamm Res
Main Authors: Yamanashi, Yuki, Ohmichi, Mika, Ohmichi, Yusuke, Ikemoto, Tatsunori, Arai, Young-Chang, Maruyama, Yohei, Otsuka, Shun, Hirai, Shuichi, Naito, Munekazu, Deie, Masataka
Format: Artigo
Jezik:Inglês
Izdano: Dove 2021
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289442/
https://ncbi.nlm.nih.gov/pubmed/34290513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S318540
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