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mRNA-Based Combination Therapy for Inflammation-Driven Osteoarthritis Induced by Monosodium Iodoacetate

<b>Background/Objectives:</b> Osteoarthritis (OA) is a progressive joint disease characterized by inflammation, cartilage degradation, and subchondral bone changes, for which effective disease-modifying therapies are lacking. Messenger RNA (mRNA)-based therapeutics offer a versatile approach to modu...

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Principais autores: Yuki Terai, Erica Yada, Hideyuki Nakanishi, Keiji Itaka
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Pharmaceutics
Fag:
osteoarthritis
mRNA therapeutics
interleukin-1 receptor antagonist (IL-1Ra)
runt-related transcription factor 1 (RUNX1)
polyplex nanomicelle
intra-articular delivery
Online adgang:https://www.mdpi.com/1999-4923/17/10/1254
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