In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax

[Image: see text] The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in silico–in vitro–in vivo approach to assess the merits of incorpor...

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Veröffentlicht in:Mol Pharm
Hauptverfasser: Koehl, Niklas J., Henze, Laura J., Bennett-Lenane, Harriet, Faisal, Waleed, Price, Daniel J., Holm, René, Kuentz, Martin, Griffin, Brendan T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289286/
https://ncbi.nlm.nih.gov/pubmed/33890794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00645
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