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Haste Makes Waste: The Interplay Between Dissolution and Precipitation of Supersaturating Formulations
Contrary to the early philosophy of supersaturating formulation design for oral solid dosage forms, current evidence shows that an exceedingly high rate of supersaturation generation could result in a suboptimal in vitro dissolution profile and subsequently could reduce the in vivo oral bioavailabil...
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| Udgivet i: | AAPS J |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627464/ https://ncbi.nlm.nih.gov/pubmed/26338234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9825-6 |
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