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Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations
[Image: see text] Liposome-based drug delivery systems composed of DOPE stabilized with cholesteryl hemisuccinate (CHMS) have been proposed as a drug delivery mechanism with pH-triggered release as the anionic form (CHSa) is protonated (CHS) at reduced pH; PEGylation is known to decrease this pH sen...
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| Publicado en: | Mol Pharm |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2021
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8289284/ https://ncbi.nlm.nih.gov/pubmed/34096310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.1c00122 |
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