Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke

Intracerebral hemorrhage associated with thrombolytic therapy with tissue plasminogen activator (tPA) in acute ischemic stroke continues to present a major clinical problem. Here, we report that infusion of tPA resulted in a significant increase in markers of neutrophil extracellular traps (NETs) in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Wang, Ranran, Zhu, Yuanbo, Liu, Zhongwang, Chang, Luping, Bai, Xiaofei, Kang, Lijing, Cao, Yongliang, Yang, Xing, Yu, Huilin, Shi, Mei-Juan, Hu, Yue, Fan, Wenying, Zhao, Bing-Qiao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288643/
https://ncbi.nlm.nih.gov/pubmed/33881503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020008913
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