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Podocyte injury augments intrarenal angiotensin II generation and sodium retention in a megalin-dependent manner

We have previously shown that podocyte injury increases the glomerular filtration of liver-derived angiotensinogen (Agt) and the generation of intrarenal angiotensin (Ang) II and that the filtered Agt is reabsorbed by proximal tubules in a manner dependent on megalin. In the present study, we aimed...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hypertension
Prif Awduron: Koizumi, Masahiro, Ueda, Kohei, Niimura, Fumio, Nishiyama, Akira, Yanagita, Motoko, Saito, Akihiko, Pastan, Ira, Fujita, Toshiro, Fukagawa, Masafumi, Matsusaka, Taiji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288562/
https://ncbi.nlm.nih.gov/pubmed/31352823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12352
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