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Xeno-nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor binding domain (RBD) on the viral S protein with angiotensin converting enzyme 2 (ACE2) on the surface of human host cells. Systematic Evolution of Ligands by Exponential Enrichment (SELEX) was us...

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Pubblicato in:bioRxiv
Autori principali: Ferreira-Bravo, Irani Alves, DeStefano, Jeffrey J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288146/
https://ncbi.nlm.nih.gov/pubmed/34282416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.07.13.452259
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