Tumor‐derived exosomal BCYRN1 activates WNT5A/VEGF‐C/VEGFR3 feedforward loop to drive lymphatic metastasis of bladder cancer

BACKGROUND: Patients with lymph node (LN) metastatic bladder cancer (BCa) present with extremely poor prognosis. BCa‐derived exosomes function as crucial bioactive cargo carriers to mediate the signal transduction in tumor microenvironment triggering tumor metastasis. However, the mechanisms underly...

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Pubblicato in:Clin Transl Med
Autori principali: Zheng, Hanhao, Chen, Changhao, Luo, Yuming, Yu, Min, He, Wang, An, Mingjie, Gao, Bowen, Kong, Yao, Ya, Yiyao, Lin, Yan, Li, Yuting, Xie, Keji, Huang, Jian, Lin, Tianxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288020/
https://ncbi.nlm.nih.gov/pubmed/34323412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.497
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