Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis

BACKGROUND: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestinal (GI) dysfunction. Oxidative stress is important for the pathophysiology of inflammation-induced enteric neuropathy and GI dysfunction. Apurinic/apyrimidinic endonuclea...

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Detalhes bibliográficos
Publicado no:Inflamm Bowel Dis
Main Authors: Sahakian, Lauren, Filippone, Rhiannon T, Stavely, Rhian, Robinson, Ainsley M, Yan, Xu Sean, Abalo, Raquel, Eri, Rajaraman, Bornstein, Joel C, Kelley, Mark R, Nurgali, Kulmira
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic Science Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287929/
https://ncbi.nlm.nih.gov/pubmed/32618996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izaa161
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