Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase

N6-methyladenosine (m6A) is a common modification on endogenous RNA transcripts in mammalian cells. Technologies to precisely modify the RNA m6A levels at specific transcriptomic loci empower interrogation of biological functions of epitranscriptomic modifications. Here, we developed a bidirectional...

詳細記述

保存先:
書誌詳細
出版年:Nucleic Acids Res
主要な著者: Xia, Zhen, Tang, Min, Ma, Jiayan, Zhang, Hongyan, Gimple, Ryan C, Prager, Briana C, Tang, Hongzhen, Sun, Chongran, Liu, Fuyi, Lin, Peng, Mei, Yutang, Du, Ruoxin, Rich, Jeremy N, Xie, Qi
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2021
主題:
Gene regulation, Chromatin and Epigenetics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287920/
https://ncbi.nlm.nih.gov/pubmed/34181729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab517
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