GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk

Glucagon-like peptide-1 (GLP-1) shows robust protective effects on β-cell survival and function and GLP-1 based therapies are successfully applied for type-2 diabetes (T2D) and obesity. Another cleavage product of pro-glucagon, Glucagon-like peptide-2 (GLP-2; both GLP-1 and GLP-2 are inactivated by...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: He, Wei, Rebello, Osmond D., Henne, Antonia, Nikolka, Fabian, Klein, Thomas, Maedler, Kathrin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287580/
https://ncbi.nlm.nih.gov/pubmed/34290670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2021.697120
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