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Sequence determinants, function, and evolution of CpG islands

In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with ∼80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with long-term gene silencing. The exceptions to such a globally hypermethylated state are CpG-rich DNA sequences called CpG i...

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Foilsithe in:Biochem Soc Trans
Main Authors: Angeloni, Allegra, Bogdanovic, Ozren
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286816/
https://ncbi.nlm.nih.gov/pubmed/34156435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200695
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