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Sequence determinants, function, and evolution of CpG islands
In vertebrates, cytosine-guanine (CpG) dinucleotides are predominantly methylated, with ∼80% of all CpG sites containing 5-methylcytosine (5mC), a repressive mark associated with long-term gene silencing. The exceptions to such a globally hypermethylated state are CpG-rich DNA sequences called CpG i...
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| Veröffentlicht in: | Biochem Soc Trans |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Portland Press Ltd.
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8286816/ https://ncbi.nlm.nih.gov/pubmed/34156435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200695 |
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