A conserved epitope III on hepatitis C virus E2 protein has alternate conformations facilitating cell binding or virus neutralization

Epitope III, a highly conserved amino acid motif of (524)APTYSW(529) on the hepatitis C virus (HCV) E2 glycoprotein, resides in the critical loop that binds to the host receptor CD81, thus making it one of the most important antibody targets for blocking HCV infections. Here, we have determined the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Deng, Lu, Hernandez, Nancy, Zhong, Lilin, Holcomb, David D., Yan, Hailing, Virata, Maria Luisa, Tarafdar, Sreya, Xu, Yanqun, He, Yong, Struble, Evi, Alter, Harvey J., Zhang, Pei
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285954/
https://ncbi.nlm.nih.gov/pubmed/34260404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104242118
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