Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus

Hepatitis C virus (HCV) envelope glycoprotein E2 has been considered as a major target for vaccine design. Epitope II, mapped between residues 427–446 within the E2 protein, elicits antibodies that are either neutralizing or nonneutralizing. The fundamental mechanism of antibody-mediated neutralizat...

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Detalhes bibliográficos
Main Authors: Deng, Lu, Zhong, Lilin, Struble, Evi, Duan, Hongying, Ma, Li, Harman, Christine, Yan, Hailing, Virata, Maria Luisa, Zhao, Zhong, Feinstone, Stephen, Alter, Harvey, Zhang, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645581/
https://ncbi.nlm.nih.gov/pubmed/23589879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305306110
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